Take control of Jak and enter a new game world for all-new missions in fantastic new platformer levels Meet a cast of characters with personal agendas. After being tortured and experimented upon in a dystopian city for two years, Jak escapes from prison and joins a rebel group, hoping for answers to his newfound dark.

JAK2 is a protein that functions as a signal to regulate cell functions. It sends messages in the cell, telling it to grow and make more cells, or else to stop when the body does not need more cells. Researchers believe that in MPD patients, the mutation in JAK2 enhances messages asking for more cell production. The result is too many blood cells which clog the blood and make it sticky. The JAK2 mutation (also called the V617F JAK2) is found in about: • half of patients with too many platelets in their blood (ET) • half of patients with too many fibroblasts in their blood (MF) • 95 per cent of patients with too many red cells in their blood (PV).

The test for the JAK2 mutation is very simple and can be done on a teaspoon of blood; results generally take 1-2 weeks. It's thought the JAK2 mutation is likely to occur as a result of some damage to the bone marrow, for example as a result of viral infections or background radiation. • half of patients with too many platelets in their blood (ET) • half of patients with too many fibroblasts in their blood (MF) • 95 per cent of patients with too many red cells in their blood (PV).

The test for the JAK2 mutation is very simple and can be done on a teaspoon of blood; results generally take 1-2 weeks. It's thought the JAK2 mutation is likely to occur as a result of some damage to the bone marrow, for example as a result of viral infections or background radiation. On 6/10/2009 Deannamarie wrote: my dad has myelofibrosis and they are talking to him about JAK 2. Could all of this help him? He was on Revlimid for one year and now they say itis not working and his spleen is getting to large and he has lost too much weight.

I am now hopeful about this JAK 2 possibility. What do you think? I understand that the JAK 2 mutation is where the myelofibrosis starts.

But not all myelofibrosis people have the JAK 2. The chemo that my husband is taking targets the JAK 2 gene mutation. He now takes 400 mg a day. This is the second month with the higher dose. The indications are that the chemo is helping.

This is the second clinical trial that he has been on. HIs spleen was getting large too, the chemo helped shrink the spleen. He has not been on Revlimid.

It is good to ask questions. Snes Usb Gamepad Driver. Retired teacher.

I was diagnosed in October 09 with Jak2. I had been going to this doctor with the same symptoms for months and they told me that I was imagining it.

I asked for all my blood tests and took them to another dr who referred me to an oncologist who found I had Jak2 but didn't know how to treat it and said that having Jak2 meant nothing. I then found an oncologist that specialised in Jak2 and he said that my symptoms where indicators of the Jak2 and he put me straight onto Agrylin in Feb 10.

My symptoms were numbness in arms and legs (not pins and needles straight numb) I couldn't walk or move my arms for days, diziness, excessive diahorea, black bruising from wearing my clothes and shoes. My platlets only went to 500 odd but it seemed to affect me.

I no longer have the numbness which is god sent and my platlets are around 160 - 200 however the agrylin (400mg) makes me sick and really tired and of late my body has become use to it and my platlets are rising again and if I miss even one dose I know that night I will have syptoms. There isn't alot of info here in Australia about Jak2. I have ET now since the Jak2 and get bad heart pains like a heart attack when I fly (I fly a lot). My blood is often that sticky that the Pathologists have problems trying to draw it. I am a very fit healthy young female. (27yr old, 59kg and 170cm). I hate having this Jak2.